发明名称 TUBULIN BINDING AGENTS AND CORRESPONDING PRODRUG CONSTRUCTS
摘要 A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.
申请公布号 WO2004087061(B1) 申请公布日期 2005.05.12
申请号 WO2004US09417 申请日期 2004.03.26
申请人 发明人 PINNEY, KEVIN, G.;MOCHARLA, VANI, P.;CHEN, ZHI;GARNER, CHARLES, M.;GHATAK, ANJAN;HADIMANI, MALLINATH;KESSLER, JIMMY;DORSEY, JAMES, M.;EDVARDSON, KLAUS;CHAPLIN, DAVID, J.;PREZIOSO, JOSEPH;JELINEK, CHRISTOPHER
分类号 A61K;A61K31/075;C07C41/00;C07C43/215;C07C43/23;C07C45/51;C07C45/64;C07C49/84;C07C205/45;C07C217/84;C07C217/94;C07C225/22;C07D233/54;C07D307/80;C07D307/81;C07D333/56;C07D333/64;C07F9/12;C07F9/18;C07F9/24;C07F9/655;C07F9/6553;(IPC1-7):C07C41/00 主分类号 A61K
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