| 发明名称 |
RETROVIRAL VECTORS FOR DELIVERY OF INTERFERING RNA |
| 摘要 |
<p>The present application relates to retroviral and lentiviral vectors comprising a promoter for RNA polymerase, a polylinker and a nucleic acid encoding a small hairpin RNA (shRNA) specific for a target gene. Upon introduction of said shRNA into cells, degradation of target gene messenger RNA is induced by RNA interference.</p> |
| 申请公布号 |
WO2005042754(A1) |
申请公布日期 |
2005.05.12 |
| 申请号 |
WO2004US34932 |
申请日期 |
2004.10.21 |
| 申请人 |
AVENTIS PHARMACEUTICALS INC.;GRUENEBERG, DORRE;BAIN, GERARD;KOTHARI, NAYANTARA |
发明人 |
GRUENEBERG, DORRE;BAIN, GERARD;KOTHARI, NAYANTARA |
| 分类号 |
C12N15/11;C12N15/867;(IPC1-7):C12N15/867;C12N5/10 |
主分类号 |
C12N15/11 |
| 代理机构 |
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代理人 |
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| 主权项 |
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