发明名称 |
N-((3-OXO-2,3-DIHYDRO-1H-ISOINDOL-1-YL)ACETYL)GUANIDINE DERIVATIVES AS NHE1-INHIBITORS FOR THE TREATMENT OF INFARCTION AND ANGINA PECTORIS |
摘要 |
<p>The present invention relates to the novel isoindolone derivatives of the formula I in which R1 to R6 have the meanings stated in the claims. The inventive compounds are suitable as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.</p> |
申请公布号 |
EP1528923(A1) |
申请公布日期 |
2005.05.11 |
申请号 |
EP20030730076 |
申请日期 |
2003.05.20 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
KLEEMANN, HEINZ-WERNER;HOFMEISTER, ARMIN;CARRY, JEAN-CHRISTOPHE;MIGNANI, SERGE;BIGOT, ANTONY;RONAN, BAPTISTE |
分类号 |
A61K45/00;A01N47/44;A61K31/4035;A61P3/06;A61P3/10;A61P7/02;A61P9/00;A61P9/02;A61P9/06;A61P9/10;A61P9/12;A61P13/08;A61P25/00;A61P25/08;A61P25/20;A61P25/22;A61P25/24;A61P33/02;A61P33/06;A61P35/00;A61P37/06;A61P43/00;C07D209/46;(IPC1-7):A61K31/403;C07C279/20;C07C277/08;A61K31/155 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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地址 |
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