发明名称 |
Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
摘要 |
This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.
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申请公布号 |
US6890928(B2) |
申请公布日期 |
2005.05.10 |
申请号 |
US20030657034 |
申请日期 |
2003.09.05 |
申请人 |
PHARMACIA CORPORATION |
发明人 |
FRESKOS JOHN N.;FOBIAN YVETTE M.;BARTA THOMAS E.;BECKER DANIEL P.;BEDELL LOUIS J.;BOEHM TERRI L.;CARROLL JEFFREY N.;DECRESCENZO GARY A.;HOCKERMAN SUSAN L.;KASSAB DARREN J.;KOLODZIEJ STEVE A.;MCDONALD JOSEPH;MISCHKE DEBORAH A.;NORTON MONICA B.;RICO JOSEPH G.;TALLEY JOHN J.;VILLAMIL CLARA I.;WANG LIJUAN JANE |
分类号 |
C07D491/048;A61K31/35;A61K31/351;A61K31/357;A61K31/381;A61K31/397;A61K31/4025;A61K31/404;A61K31/41;A61K31/4178;A61K31/4184;A61K31/42;A61K31/423;A61K31/4245;A61K31/427;A61K31/428;A61K31/4355;A61K31/4433;A61K31/445;A61K31/453;A61K31/454;A61K31/4545;A61K31/455;A61K31/4709;A61K31/4725;A61K31/506;A61K31/53;A61K31/5377;A61P1/02;A61P1/04;A61P1/16;A61P7/00;A61P7/02;A61P7/04;A61P9/00;A61P9/04;A61P9/10;A61P11/00;A61P13/12;A61P17/02;A61P17/06;A61P19/00;A61P19/02;A61P25/00;A61P25/18;A61P25/28;A61P27/02;A61P27/16;A61P29/00;A61P31/04;A61P35/00;A61P35/04;A61P37/02;A61P37/06;A61P39/00;A61P43/00;C07D211/66;C07D309/08;C07D309/12;C07D401/12;C07D405/12;C07D405/14;C07D407/12;C07D409/12;C07D409/14;C07D413/12;C07D413/14;C07D417/12;C07D417/14;C07D491/04;(IPC1-7):A61K31/445;C07D401/02 |
主分类号 |
C07D491/048 |
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