发明名称 |
Method for producing 4-(heteroaryl-methyl)-halogen-1(2H)-phthalazinones |
摘要 |
A process for the production of 4-(heteroaryl-methyl)-halogen-1(2H)-phthalazinones, especially 4-(4-pyridylmethyl)-1(2H)-phthalazinone, is described, which is characterized by the reaction of phthalidyl-3-triphenylphosphonium salt with 4-pyridine aldehyde in the presence of a basic adjuvant, subsequent reaction with hydrazine hydrate and subsequent acid treatment, whereby this process avoids the technical safety and environmental problems of the known processes.
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申请公布号 |
US6891041(B2) |
申请公布日期 |
2005.05.10 |
申请号 |
US20030168794 |
申请日期 |
2003.06.11 |
申请人 |
PETROV ORLIN;HEINER THOMAS;NEH HERRIBERT;KRUGER MARTIN |
发明人 |
PETROV ORLIN;HEINER THOMAS;NEH HERRIBERT;KRUGER MARTIN |
分类号 |
C07D401/06;C07D403/06;(IPC1-7):C07D401/06 |
主分类号 |
C07D401/06 |
代理机构 |
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代理人 |
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地址 |
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