发明名称 |
6,9-DISUBSTITUTED 2-[TRANS-(4-AMINOCYCLOHEXYL)AMINO]PURINES |
摘要 |
Compounds of Formula (I) wherein R is selected from the group consisting of R2, R2NH-, or R3R4N-R5-, and R1 is selected from the group consisting of cyclopentyl, cyclopentenyl and isopropyl, and t he pharmaceutically acceptable salts, optical isomers, and hydrates thereof. The invention provides a method of inhibiting cell cycle progression, a method of inhibiting cyclin dependent kinases, particularly cdk-2, a method of preventing apoptosis in neuronal cells and a method of inhibiting the development of neoplasms, a composition comprising an assayable amount of a compound of Formula (I) in admixture or otherwise in association with an inert carrier, and a pharmaceutical composition comprising an effective inhibitory amount o f a compound of Formula (I) in admixture or otherwise in association with one or more pharmaceutically acceptable carriers or excipients.
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申请公布号 |
CA2320474(C) |
申请公布日期 |
2005.05.10 |
申请号 |
CA19992320474 |
申请日期 |
1999.02.18 |
申请人 |
AVENTIS PHARMACEUTICALS INC. |
发明人 |
PEET, NORTON P.;BITONTI, ALAN J.;SHUM, PATRICH W.K.;DUMONT, JENNIFER A.;MUNSON, H. RANDALL;BORCHERDING, DAVID R. |
分类号 |
C07D473/16;A61K31/52;A61P25/00;A61P35/00;A61P35/02;A61P43/00;C07D473/00;(IPC1-7):C07D473/16 |
主分类号 |
C07D473/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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