摘要 |
The present invention relates to a new method for the preparation of radiopharmaceuticals based on technetium and rhenium. The method involves the reaction of a salt of the formula [M(CO)<SUB>3</SUB>(X<SUP>m</SUP>)<SUB>3</SUB>]<SUP>(1+3m)</SUP>, wherein M is selected from a radioisotope of rhenium, technetium and any other radioisotope that binds in a similar fashion, X is any suitable ligand and m is the formal charge for ligand X, with a nido-dicarbollide dianion of the formula [nido-(C<SUB>2</SUB>B<SUB>9</SUB>H<SUB>11</SUB>)]<SUP>2-</SUP> and functional derivatives thereof. The method has been shown to be applicable to the preparation of radiopharmaceuticals at the tracer level.
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