The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome into the cell cytoplasm. The invention provides for methods which employ peptides or peptide derivatives to inhibit Flavivirus:cell fusion. The present invention is based in part on the discovery that El envelope glycoprotein of hepaciviruses and E2 envelope glycoprotein of pestivirus have previously undescribed structures, truncated class II fusion proteins. The present invention provides peptides and methods of treatment and prophylaxis of diseases induced by Flaviviruses.
申请公布号
WO2004044220(A3)
申请公布日期
2005.05.06
申请号
WO2003US35666
申请日期
2003.11.07
申请人
THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND;THE ROCKEFELLER UNIVERSITY;GARRY, ROBERT, F.;DASH, SRIKANTA;COY, DAVID, H.;MCKEATING, JANE, A.
发明人
GARRY, ROBERT, F.;DASH, SRIKANTA;COY, DAVID, H.;MCKEATING, JANE, A.