LEECH EXTRACTS FOR STENTS

摘要

The invention relates to a stable destabilase complex in the form of a monomer, which is capable of aggregating into a polymer destabilase complex forming a liposome and which can be obtained from medicinal leeches using the following method comprising: affinity chromatography with 6-keto-prostaglandin antibodies which are immobilised on a suitable column; and high ionic strength elution of the destabilase complex, said complex having an antithrombin activity of at least 700 ATU/mg, a plasma recalcification time of at least 800 APC/mg, a fibrinolytic activity of at least 40mm<2>/mg and an immunomodulating activity.