发明名称 |
MONOCLONAL ANTIBODIES THAT ARE CROSS-REACTIVE AGAINST BACTERIAL COLLAGEN BINDING PROTEINS |
摘要 |
Cross-reactive monoclonal antibodies are provided which are generated from peptides from Enterococcus faecalis, including the ACE40 and the ACE19 protein, and the CNA19 peptide from Staphylococcus aureus, and which can bind to the collagen-binding proteins from bacteria and from a variety of species including enterococcal bacteria, staphylococcal bacteria and streptococcal bacteria. These monoclonal antibodies may then be formed into suitable pharmaceutical compositions, and they are thus particularly effective in providing methods of treating or preventing bacterial infections from a wide range of bacterial species.
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申请公布号 |
WO03072607(A8) |
申请公布日期 |
2005.05.06 |
申请号 |
WO2003US05040 |
申请日期 |
2003.02.21 |
申请人 |
UNIVERSITA DEGLI STUDI DI PAVIA;BATES, SARAH, E.;SPEZIALE, PIETRO;VISAI, LIVIA;GIAMPIERO, PIETROCOLA |
发明人 |
SPEZIALE, PIETRO;VISAI, LIVIA;GIAMPIERO, PIETROCOLA |
分类号 |
A61K31/655;A61K39/09;C07K16/12;(IPC1-7):C07K16/00;A61K61/06;A01N37/36;G01N33/53 |
主分类号 |
A61K31/655 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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