COMPUESTOS DERIVADOS DE ANILINA, AGONISTAS DE RECEPTORES ACTIVADORES DEL PROLIFERADOR DE PEROXISOMA (PPAR); PROCEDIMIENTO PARA SU PREPARACION; COMPOSICIONES FARMACEUTICAS; Y USO EN ENFERMEDADES MODULADAS POR AGONISTAS PPAR DELTA Y/O PPAR ALFA, COMO D

摘要

This invention relates to compounds of the formula wherein X is N and Y is S or O; or X is S or O and Y is N; R¹ is hydrogen or C_1-7-alkyl; R² and R³ independently from each other are selected from the group consisting of hydrogen, C_1-7-alkyl and C_1-7-alkoxy; R⁴, R⁵, R⁶, and R⁷ independently from each other are selected from the group consisting of hydrogen, C_1-7-alkyl, C_3-7-cycloalkyl, halogen, C_1-7-alkoxy, C_1-7-alkyl-C_1-7-alkoxy-C_1-7-alkyl, C_2-7-alkenyl, C_2-7-alkinyl, fluoro-C_1-7-alkyl and cyano; R⁸ is selected from the group consisting of hydrogen, C_1-7-alkyl, C_3-7-cycloalkyl and fluoro-C_1-7-alkyl; R⁹ is selected from the group consisting of hydrogen, C_1-7-alkyl, C_2-7-alkinyl, C_3-7-cycloalkyl and fluoro-C_1-7-alkyl; R¹⁰ is selected from the group consisting of hydrogen, C_1-7-alkyl, C_2-7-alkinyl, C_3-7-cycloalkyl and fluoro-C_1-7-alkyl; R¹¹ is aryl or heteroaryl; N is 0, 1 or 2; and all enantiomers and pharmaceutically acceptable salts and/or esters thereof and their use as PPAR activators.