METHOD OF TREATING RHEUMATOID ARTHRITIS USING NF-kB INHIBITORS

摘要

The present invention concerns a method of treating rheumatoid arthritis by diagnosing that a person is in need of treatment for rheumatoid arthritis and administering a therapeutically effective amount of a ligand which modulates NF-kB transcription factor by interaction with estrogen receptor ER-alpha, estrogen receptor ER-beta, or both ER-alpha and ER- beta estrogen receptors with a substantial absence of creatine kinase stimulation. In certain embodiments, the administration is with a substantial absence of uterotropic activity.