DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 17 (GPR17)

摘要

The invention provides a human GPR17 which is associated with the cardiovascular disorders, dermatological disorders, endocrine system and hormone disorders, metabolic diseases, cancer disorders, inflammatory diseases, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, muscle-skeleton disorders, neurological disorders, urological disorders and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, dermatological disorders, endocrine system and hormone disorders, metabolic diseases, cancer disorders, inflammatory diseases, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, muscle-skeleton disorders, neurological disorders, urological disorders and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR17 as well as pharmaceutical compositions comprising such compounds.