发明名称 |
MOLECULES THAT SELECTIVELY HOME TO VASCULATURE OF PRE-MALIGNANT DYSPLASTIC LESIONS OR MALIGNANCIES |
摘要 |
The present invention provides a conjugate that contains a therapeutic moiety linked to a homing peptide or peptidomimetic which selectively homes to vasculature of pre-malignant dysplastic skin and which includes the amino acid sequence SRPRR (SEQ ID NO: 1) or a conservative variant or peptidomimetic thereof. The present invention further provides a conjugate containing a therapeutic moiety linked to a homing peptide or peptidomimetic which selectively homes to vasculature of malignant skin and which includes the amino acid sequence CGKRK (SEQ ID NO: 6) or the amino acid sequence CDTRL (SEQ ID NO: 7), or a conservative variant or peptidomimetic of one of these sequences. |
申请公布号 |
WO2005039495(A2) |
申请公布日期 |
2005.05.06 |
申请号 |
WO2004US34918 |
申请日期 |
2004.10.21 |
申请人 |
THE BURNHAM INSTITUTE;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;HANAHAN, DOUGLAS;RUOSLAHTI, ERKKI |
发明人 |
HANAHAN, DOUGLAS;RUOSLAHTI, ERKKI |
分类号 |
A61K;A61K38/00;A61K38/03;A61K38/08;A61K38/12;A61K47/48;A61K49/00 |
主分类号 |
A61K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|