发明名称 |
Treatment of hypercholesterolemia or diabetes associated angiogenic defects |
摘要 |
The present invention relates to the use of a plasmid encoding a fibroblast growth factor as therapeutic agent for the prevention and treatment of hypercholesterolemia or diabetes associated myocardial or skeletal angiogenic defects. The present invention also relates to a method for enhancing formation of both collateral blood vessels and arterioles in myocardial or skeletal ischemic tissues in a mammalian subject suffering from hypercholesterolemia or diabetes. The present invention further relates to a method of promoting collateral blood vessels in ischemic myocardial or skeletal tissues without inducing VEGF-A factor expression and causing edema in the treated muscles.
|
申请公布号 |
US2005096286(A1) |
申请公布日期 |
2005.05.05 |
申请号 |
US20040861906 |
申请日期 |
2004.06.07 |
申请人 |
CENTELION SAS |
发明人 |
CARON ALEXIS;EMMANUEL FLORENCE;FINIELS FRANCOISE S.;MICHELET SANDRINE;CARON ANNE;ROUY DIDIER;BRANELLEC DIDIER;SCHWARTZ BERTRAND |
分类号 |
A61K38/18;A61K45/06;A61K48/00;A61P9/10;(IPC1-7):A61K48/00 |
主分类号 |
A61K38/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|