Cannabinoid receptor interacting proteins and methods of use

摘要

Novel polypeptides capable of interacting with the CB1 cannabinoid receptor. Also provided are genomic and cDNA sequences encoding the CB1 receptor interacting proteins 1a and 1b (CRIP1a and CRIP1b) and antibodies to the CRIP1a and CRIP1b proteins. Also provided are methods of modulating the activity of the CB1 receptor and methods of screening for modulators of CRIP1a and CRIP1b activity on the CB1 receptor.