发明名称 |
Compositions and method for treating hepatitis virus infection |
摘要 |
The present invention provides compositions and methods of treating hepatitis virus infection, particularly hepatitis C virus infection. The invention provides methods of treating a hepatitis virus infection, involving administering a first form and a second form of IFN-alpha to provide a multiphasic pharmacokinetic profile. The multiphasic antiviral agent serum concentration profile that is achieved effects an initial rapid drop in viral titer, followed by a further decrease in viral titer over time, to achieve a sustained viral response. The invention further provides compositions that are effective in achieving a multiphasic IFN-alpha profile. Compositions of the invention comprise at least a first form of interferon-alpha (IFN-alpha) that has a first pharmacokinetic profile and a second form of IFN-alpha that has a second pharmacokinetic profile, where the second form of IFN-alpha has a longer mean residence time than that of the first form of IFN-alpha. The invention further provides compositions comprising C-terminally modified IFN-alpha.
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申请公布号 |
US2005095224(A1) |
申请公布日期 |
2005.05.05 |
申请号 |
US20040496999 |
申请日期 |
2004.12.17 |
申请人 |
RADHAKRISHNAN RAMACHANDRAN;VISOR GARY;VAN VLASSELAER PETER;LOVE RICHARD B. |
发明人 |
RADHAKRISHNAN RAMACHANDRAN;VISOR GARY;VAN VLASSELAER PETER;LOVE RICHARD B. |
分类号 |
A61K38/21;A61K47/48;A61P1/16;A61P9/00;A61P9/12;A61P31/12;A61P35/00;A61P43/00;C07K14/56;C07K17/08;(IPC1-7):A61K38/21 |
主分类号 |
A61K38/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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