Factorial chemical libraries

摘要

A method and library for determining the sequence of monomers in a polymer which is complementary to a receptor. The method provides for formation of pooled ( 6 ) and separate ( 10, 12 ) products. Separate products are subjected only to subsequent pooled coupling steps. Each pooled product is subsequently divided for formation of pooled and separate products. The resulting polymer library includes groups of polymer products. A first group of products ( 42 ) is used to identify the monomer at a first location in a polymer that is complementary to a receptor. A second group of products ( 44 ) is used to identify the monomer at a second location in a polymer that is complementary to a receptor.