发明名称 |
ECHINOCANDIN PHARMACEUTICAL FORMULATIONS CONTAINING MICELLE-FORMING SURFACTANTS |
摘要 |
<p>Pharmaceutical formulations are described comprising an echinocandin compound or echinocandin/carbohydrate complex and a pharmaceutically acceptable micelle-forming surfactant in a non-toxic aqueous solvent such that the solubilization of the echinocandin compound is optimized and the ability to freeze-dry the solution is maintained. Both the solution and freeze-dried formulations have increased stability. A bulking agent, tonicity agent buffer and/or a stabilizing agent may optionally be added to the formulations to further enhance the stability of the formulation.</p> |
申请公布号 |
EP1156782(B1) |
申请公布日期 |
2005.05.04 |
申请号 |
EP20000910391 |
申请日期 |
2000.03.02 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
MILTON, NATHANIEL;MODER, KENNETH, PHILIP;SABATOWSKI, JAMES, LAWRENCE;SWEETANA, STEPHANIE, ANN |
分类号 |
A61K9/08;A61K9/107;A61K9/19;A61K31/407;A61K38/00;A61K38/12;A61P31/10;(IPC1-7):A61K9/107 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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