发明名称 |
STABILIZED FORMULATIONS COMPRISING AMLODIPINE MALEATE |
摘要 |
The present invention is concerned with means for stabilising amlodipine maleate of the formula: (see above formula) to prevent the formation of unwanted Michael adduct and with stabilised pharmaceutical compositions obtained thereby. For stabilising amlodipine maleate, an acid (such as maleic acid, phosphoric acid, ascorbic acid or sorbic acid) having a pK1 greater than 1.5 is employed.
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申请公布号 |
CA2390636(C) |
申请公布日期 |
2005.05.03 |
申请号 |
CA20022390636 |
申请日期 |
2002.06.13 |
申请人 |
PFIZER INC. |
发明人 |
BILLOTTE, ANNE;PAVITT, SHARON;PETTMAN, ALAN JOHN;SMITH, ZENA ELIZABETH FLORENCE |
分类号 |
C07D211/90;A61K9/14;A61K9/16;A61K9/20;A61K9/48;A61K31/375;A61K31/4422;A61K33/42;A61K47/04;A61K47/12;A61K47/22;A61K47/26;A61K47/36;A61K47/38;A61P9/10;A61P9/12;A61P43/00;(IPC1-7):A61K31/44;A61K45/08 |
主分类号 |
C07D211/90 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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