| 摘要 |
The invention relates to pseudolaric acid-B derivatives of general formula (I), wherein (a) R<SUB>1 </SUB>is cyano, heterocyclyl, COXR' or CON(R'')<SUB>2</SUB>, wherein X is O or NH, R' is H, cycloalkyl, alkyl, heterocyclic alkyl or arylalkyl, each R'' is independently alkyl, cycloalkyl or heterocyclicalkyl; (b) R<SUB>2 </SUB>is H, alkylacyl, arylalkylacyl, arylacyl or heterocyclylacyl; (c) R<SUB>3 </SUB>is COXY, amino or halogen, wherein X is O or NH, Y is H, NH<SUB>2</SUB>, hydroxy, alkyl, cycloalkyl, heterocyclicalkyl, hetroatom-substituted alkyl, tertiary amino-substituted ammonioalkyl, aryl, arylalkyl or polyhydroxyalkyl. The invention also relates to processes for preparing such derivatives and antitumor or antifungal pharmaceutical compositions containing the same.
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