发明名称 |
Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug |
摘要 |
Bifunctional molecules and methods for their use are provided. The subject bifunctional molecules are conjugates of a drug moiety and a pharmacokinetic modulating moiety, where these two moieties are optionally joined by a linking group. The bifunctional molecules are further characterized in that they exhibit at least one modulated pharmacokinetic property upon administration to a host as compared to a free drug control. The subject bifunctional molecules find use in a variety of therapeutic applications.
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申请公布号 |
US6887842(B1) |
申请公布日期 |
2005.05.03 |
申请号 |
US20000716841 |
申请日期 |
2000.11.17 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
BRIESEWITZ ROGER;CRABTREE GERALD R.;WANDLESS THOMAS J. |
分类号 |
A61K47/48;(IPC1-7):A61K31/00;A61K38/00;C12N11/02;C07K1/00;C07K17/02 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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