发明名称 |
Pharmaceutical preparation of recombinant factor VIII lyophilized without albumin as a stabilizer |
摘要 |
Disclosed is a lyophilized preparation of recombinant factor VIII used as a therapeutic preparation of hemophilia A. The lyophilized preparation of recombinant factor VIII is prepared by performing lyophilization using a mixture comprising 6 to 100 mM of L-arginine, 3.5 to 50 mM of L-isoleucine, and 10 to 100 mM of L-glutamic acid as a stabilizer for stabilizing the recombinant factor VIII which exhibits an unstable activity during lyophilization, rather than using human blood derived albumin.
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申请公布号 |
US6887852(B1) |
申请公布日期 |
2005.05.03 |
申请号 |
US20040912167 |
申请日期 |
2004.08.06 |
申请人 |
KOREA GREEN CROSS CORPORATION |
发明人 |
PAIK SANG HOON;SHIN YONG NAM;KIM JEAN MAN;HUH JAE WOOK;LEE JUNG SIK;KWON KI SUNG;CHUN JI HYUN |
分类号 |
A61K9/19;A61K38/37;A61K47/18;C07K14/755;(IPC1-7):A61K38/00;A61K35/14;C12P21/02 |
主分类号 |
A61K9/19 |
代理机构 |
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代理人 |
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地址 |
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