NOVEL LIPOIC ACID DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

A SUBJECT OF THE INVENTION IS NOVEL DERIVATIVES OF LIPOIC ACID,WHICH HAVE AN INHIBITORY ACTIVITY ON NO-SYNTHASE ENZYMES PRODUCING NITROGEN MONOXIDE NO AND/OR AGENTS WHICH ALLOW THE REGENERATION OF ANTIOXIDANTS OR ENTITIES WHICH TRAP THE REACTIVEOXYGEN SPECIES (ROS) AND WHICH INTERVENE IN A MORE GENERAL FASHION IN THE REDOX STATUS OF THIOL GROUPS. A SUBJECT OF THE INVENTION IS ALSO THEIR PREPARATION METHODS, THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE FOR THERAPEUTIC PURPOSES, IN PARTICULAR THEIR USE AS NO-SYNTHASE INHIBITORS AND/OR AS AGENTS WHICH INTERVENE IN A MORE GENERAL FASHION IN THE REDOX STATUS OF THIOL GROUPS.