ORAL PHARMACEUTICAL DOSAGE FORMS COMPRISING A PROTON PUMP INHIBITOR AND A NSAID

摘要

AN ORAL PHARMACEUTICAL DOSAGE FORM COMPRISING AN ACID SUSCEPTIBLE PROTON PUMP INHIBITOR AND ONE OR MORE NSAIDS (2) IN A FIXED FORMULATION, WHEREIN THE PROTON PUMP INHIBITOR IS PROTECTED BY AN ENTERIC COATING LAYER (1). THE FIXED FORMULATION IS IN THE FORM OF AN ENTERIC COATING LAYERED TABLET, A CAPSULE OR A MULTIPLE UNIT TABLETED DOSAGE FORM. THE MULTIPLE UNIT DOSAGE FORMS ARE MOST PREFERRED. THE NEW FIXED FORMULATION IS ESPECIALLY USEFUL IN TREATMENT OF GASTROINTESTINAL SIDE-EFFECTS ASSOCIATED WITH NSAID TREATMENT.FIGURE 4