Pyrrole substituted 2-indolinone protein kinase inhibitors

摘要

Disclosed are compounds of formula (I), wherein: R1 is H, halo, alkyl, cycloalkyl, aryl, heteroaryl, heteroalicyclic, hydroxy, alkoxy, -(CO)R15, -NR13R14, -(CH2)rR16 and -C(O)NR8R9, R2 is H, halo, alkyl, trihalomethyl, hydroxy, alkoxy, -NR13R14, -NR13C(O)R14, -C(O)R15, aryl, heteroaryl, and -S(O)2NR13R14, R3 is H, halo, alkyl, trihalomethyl, hydroxy, alkoxy, -C(O)R15, -NR13R14, aryl, heteroaryl, -NR13S(O)2R14, -S(O)2NR13R14, -NR13C(O)R14 and -NR13C(O)OR14, R4 is H, halo, alkyl, hydroxy, alkoxy and -NR13R14, R5 is H, alkyl and -C(O)R10, R6 is H, alkyl and -C(O)R10, R7 is H, alkyl, aryl, heteroaryl, -C(O)R17 and -C(O)R10, or R6 and R7 may combine to form -(CH2)4-, -(CH2)5- or -(CH2)6-, and the remaining substituents are defined herein. The compounds are used in the manufacture of medicaments for the treatment of protein kinase related disorders in an organism.