Stabilized oral pharmaceutical composition

摘要

An orally deliverable pharmaceutical composition comprising (a) a selective cyclooxygenase-2 inhibitory drug of formula (I), wherein R4 is hydrogen or a C1-4 alkyl or alkoxy group, X is N or CR5 where R5 is hydrogen or halogen, and Y and Z are independently carbon or nitrogen atoms defining adjacent atoms of a five- to six-membered ring that is unsubstituted or substituted at one or more positions with oxo, halo, methyl or halomethyl groups in a therapeutically and/or prophylactically effective amount and (b) a solvent liquid that comprises at least one pharmaceutically acceptable polyethylene glycol and at least one pharmaceutically acceptable free radical-scavenging antioxidant, wherein at least 15% by weight of the drug is in dissolved or solubilised form in the solvent liquid.