| 摘要 |
Disclosed are fumaric acid amide compounds of formula (I), wherein: R1 is OR3 or a D- or L-amino acid radical -NH-CHR4-COOH bonded via an amide bond, wherein R3 is H, optionally substituted alkyl, phenyl or aralkyl and R4 is a side chain of a natural or synthetic amino acid, and R2 is a D- or L-amino radical -NH-CHR5-COOH bonded via an amide bond, wherein R5 is a side chain of a natural or synthetic amino acid. The compounds are used in the manufacture of medicaments for the therapy of autoimmune diseases, for use in transplantation medicine, for therapy of mitochondrial diseases and for therapy of NF-kappaB mediated diseases.
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