N-[(substituted five-membered di- or triaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia

摘要

Disclosed are substituted guanidine compounds of formula I, wherein: Z is a heterocyclic radical or formula (i), (ii), (iii) or (iv), for which the further substituents are defined herein. The compounds are used in the manufacture of medicaments for reducing tissue damage resulting from ischemia in a mammal