发明名称 |
Polyol-ifn-beta conjugates. |
摘要 |
PEG-IFN- beta conjugates, where a PEG moiety is covalently bound to Cys<17> of human IFN- beta , are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN- beta . |
申请公布号 |
HK1038194(A1) |
申请公布日期 |
2005.04.29 |
申请号 |
HK20010109037 |
申请日期 |
2001.12.24 |
申请人 |
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
发明人 |
NABIL EL TAYAR;MILTON HARRIS;WAYNE SAWLIVICH;ROBERTS, MICHAEL, J. |
分类号 |
A61K47/34;A61K38/21;A61K47/48;A61P31/00;A61P35/00;A61P37/06;A61P39/00;(IPC1-7):A61K |
主分类号 |
A61K47/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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