HYDROLYSIS OF [R(R*,R*)]-2 -(4-FLUOROPHENYL) -BETA, DELTA -DIHYDROXY- 5-(1-METHYLETHYL) -3-PHENYL-4 -[(PHENYLAMINO) CARBONYL]- 1H-PYRROLE-1 -HEPTANOIC ACID ESTERS WITH CALCIUM HYDROXIDE.

摘要

The present invention provides a process for preparing atorvastatin hemi-calcium from an atorvastatin ester derivative with calcium hydroxide. The process is conveniently incorporated into a process for preparing atorvastatin hemi-calcium from an acetonide protected, ester protected bgr;,dgr;-dihydroxy heptanoic acid precursor compound by a first acid hydrolysis step followed by base hydrolysis with calcium hydroxide. The latter process may be performed as a one-pot process.