发明名称 |
ALTERATION OF Fc-FUSION PROTEIN SERUM HALF-LIVES BY MUTAGENESIS OF POSITIONS 250, 314 AND/OR 428 OF THE HEAVY CHAIN CONSTANT REGION OF IG |
摘要 |
<p>The present invention provides for a modified Fc-fusion protein in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified Fc-fusion protein, thereby altering the binding affinity for FcRn and/or the serum half-life in comparison to the unmodified Fc-fusion protein.</p> |
申请公布号 |
WO2005037867(A1) |
申请公布日期 |
2005.04.28 |
申请号 |
WO2004US34440 |
申请日期 |
2004.10.15 |
申请人 |
PROTEIN DESIGN LABS, INC.;HINTON, PAUL, R.;TSURUSHITA, NAOYA |
发明人 |
HINTON, PAUL, R.;TSURUSHITA, NAOYA |
分类号 |
A61K39/395;C07K14/54;C07K14/705;C07K14/715;C07K16/00;C07K16/08;C07K16/24;C07K16/28;C07K16/44;(IPC1-7):C07K16/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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