发明名称 |
Chemically modified enzymes with multiple charged variants |
摘要 |
This invention provides modified enzymes comprising one or more amino acid residues replaced by cysteine residues, where the cysteine residues are modified by replacing the thiol hydrogen in the cysteine residues with a substituent group providing a thiol side chain comprising a multiply charged moiety. The enzymes show improved interaction and/or specificity and/or activity with charged substrates.
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申请公布号 |
US2005089966(A1) |
申请公布日期 |
2005.04.28 |
申请号 |
US20040993827 |
申请日期 |
2004.11.19 |
申请人 |
DAVID BENJAMIN G.;JONES JOHN B.;BOTT RICHARD R. |
发明人 |
DAVID BENJAMIN G.;JONES JOHN B.;BOTT RICHARD R. |
分类号 |
G01N33/483;C11D3/386;C12N9/50;C12N9/54;C12N9/64;C12N15/55;C12Q1/34;C12R1/07;(IPC1-7):C12N9/54;C07H21/04;C12N15/74 |
主分类号 |
G01N33/483 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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