| 摘要 |
PROBLEM TO BE SOLVED: To provide a biologically stable liquid composition of FVIII (factor VIII), vWF (von Willebrand factor), or a FVIII/vWF complex derived from a human. SOLUTION: This biologically stable liquid composition of the FVIII, the vWF, or the FVIII/vWF complex derived from the human contains a concentrate of the FVIII, the vWF, or the FVIII/vWF complex derived from the human together with a chelating agent for a metal, a specified ligand, and, preferably a protease inhibitor, so that activity of the vWF is protected, a defending effect on the FVIII is maintained, and stability of the FVIII/vWF is improved. It is preferable that EDTA (ethylenediaminetetraacetic acid) is used as the chelating agent for the metal, heparin is used as the ligand, and a concentration of the protease inhibitor is more than 0.01 IU. COPYRIGHT: (C)2005,JPO&NCIPI
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