COMPOSITIONS AND METHODS FOR INCREASING CHOLESTEROL EFFLUX AND RAISING HDL USING ATP BINDING CASSETTE TRANSPORTER PROTEIN ABC1

摘要

PROBLEM TO BE SOLVED: To provide a composition for increasing cholesterol efflux and raising HDL using ATP binding cassette transporter ABC1. SOLUTION: There are provided new ABC1 polypeptides and nucleic acid molecules encoding the same, recombinant vectors, host cells, and compositions comprising ABC1 polynucleotides, as well as methods for producing ABC1 polypeptides, antibodies that bind specifically to ABC1 polypeptides; methods for increasing cholesterol efflux and to methods for increasing ABC1 expression and activity; methods for identifying compounds that modulate the expression of ABC1 and methods for detecting the comparative level of ABC1 polypeptides and polynucleotides in a mammalian subject; and kits and compositions suitable for screening compounds to determine the ABC1 expression modulating activity of the compound, and kits and compositions suitable to determine whether or not a compound modulates ABC1-dependent cholesterol efflux. COPYRIGHT: (C)2005,JPO&NCIPI