DERIVATIVES OF N-[PHENYL(PYRROLIDINE-2-YL)METHYL]BENZAMIDE AND N-[(AZEPAN-2-YL)PHENYLMETHYL]BENZAMIDE, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS

摘要

The invention relates to compounds having general formula (I), wherein: n represents the number 1 or 3; R1 represents either H or a cycloalkyl, cycloalkylalkyl, phenylalkyl, alkenyl, alkynyl group; X represents either H or one or more substituents selected from among halogen atoms and the trifluoromethyl, alkyl and alkoxy groups; and R2 represents H, or one or more substituents selected from among the halogen atoms and the trifluoromethyl, alkyl, alkoxy, cycloalkyl, phenyl, cyano, acetyl, benzoyl, S-alkyl, alkyl-sulfonyl, carboxy and alkoxycarbonyl groups, or a group having formula NR3R4, SO2NR3R4 or CONR3R4, in which R3 and R4 each represent H or an alkyl or cycloalkyl group or, together with the nitrogen atom, form a pyrrolidine, piperidine or morpholine ring. The invention also relates to the use of said compounds in therapeutics.