发明名称 |
METHOD FOR PURIFYING 20(S)-CAMPTOTHECIN |
摘要 |
The invention relates to a method for purifying 20(S) camptothecin by transforming the lactone ring of the 20(S) camptothecin into a carboxylate salt with the help of an aqueous base, hydrogenating the mixture that is obtained in the presence of a transition metal catalyst, acidifying the aqueous phase to form camptothecin crystals, adding a polar aprotic solvent, optionally heating and cooling the mixture and separating the camptothecin crystals.
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申请公布号 |
EA005618(B1) |
申请公布日期 |
2005.04.28 |
申请号 |
EA20030000837 |
申请日期 |
2002.02.09 |
申请人 |
BOEHRINGER INGELHEIM PHARMA GMBH &CO. KG |
发明人 |
SOBOTTA, RAINER;RAPP, ARMIN |
分类号 |
B01D9/02;C07D491/14;C07D491/22;(IPC1-7):C07D491/04 |
主分类号 |
B01D9/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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