Aminoalcohol derivatives as beta-3 adrenergic receptor agonists

摘要

The present invention relates to a compound formula [I] wherein R1 and R⁵ are each independently hydrogen, halogen, lower alkyl, etc., R² is hydrogen or an amino protective group, x is bond, -o-o, -O-CH₂-, etc., y is in which Z is bond, -O-(CH₂)_m- (in which m is 1 to 4), etc., R³ is lower alkanoyl, carboxy, lower alkoxycarbonyl, etc., and R⁴ is hydrogen, halogen, hydroxy, phenoxy, lower alkyl, lower alkoxy, etc., and n is 0, 1 or 2, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.