| 摘要 |
Benzo (d)iso-selenium-azole derivatives (I), their pharmaceutically acceptable salts, precursors and metabolites are new. Benzo (d)iso-selenium-azole derivatives of formula (I), their pharmaceutically acceptable salts, precursors and metabolites are new. R1>: H or halogen atoms, alkyl or alkoxy groups. R2>: H atom, alkyl-, carboxy-, alkoxycarbonyl-carboxamido-, or aryl-, or hetero-aryl-groups. Y: a valency sign, (1-4C) straight or branched alkene groups, where certain alkene groups may be interposed by arylene groups; n = 0 or 1; Q: H atom OH or oxy (O) group; Z: single or double bond. Precursors and metabolites are amines, nitroxides, diamagnetic N-hydroxy-compounds, oxo-immonium groups, conjugated thiols, and compounds resulting from opening the iso-selenium-azole ring, inclusive of salts. (I) are pharmaceutically active in treating various forms of impaired health symptoms caused by reactive oxidative derivatives or oxidative damage caused by reactive nitrogen derivatives. |
