发明名称 |
Stable polymorph of N-(3-ethynylphenyl)-6, 7-bis (2-methoxyethoxy)-4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof |
摘要 |
The present invention relates to a stable crystalline form of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride designated the B polymorph, its production in essentially pure form, and its use. The invention also relates to the pharmaceutical compositions containing the stable polymorph B form of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine as hydrochloride, as well other forms of the compound, and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound.
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申请公布号 |
US2005090500(A1) |
申请公布日期 |
2005.04.28 |
申请号 |
US20040992266 |
申请日期 |
2004.11.18 |
申请人 |
OSI PHARMACEUTICALS, INC. |
发明人 |
NORRIS TIMOTHY;RAGGON JEFFREY W.;CONNELL RICHARD D.;MOYER JAMES D.;MORIN MICHAEL J.;KAJIJI SHAMA M.;FOSTER BARBARA A.;FERRANTE KAREN J.;SILBERMAN SANDRA L. |
分类号 |
A61K31/517;A61K45/06;C07D239/94;(IPC1-7):A61K31/498 |
主分类号 |
A61K31/517 |
代理机构 |
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代理人 |
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地址 |
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