| 摘要 |
The present application concerns methods of inducing a pancreatic endocrine phenotype and function, including pancreatic hormone production, in a non-pancreatic and non-endocrine cell/tissue, particularly in a liver cell/tissue. This is achieved by contacting said non-pancreatic and non-endocrine cell/tissue with a PDX-1 inducer compound, such as a nucleic acid encoding a PDX-1 polypeptide, a neuroD polypeptide or a betacellulin peptide, eventually in the presence of nicotinamide, EGF, activin A, HGF, exedin GLP-1 or betacellulin.
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