The invention encompasses processes for the synthesis of cilexetil trityl candesartan from the reaction of trityl candesartan with cilexetil halide in the presence of a base and a low boiling organic solvent. Optionally, the reaction may be conducted in the presence of a phase transfer catalyst.
申请公布号
WO2005037821(A2)
申请公布日期
2005.04.28
申请号
WO2004US34540
申请日期
2004.10.18
申请人
TEVA PHARMACEUTICAL INDUSTRIES LTD.;TEVA PHARMACEUTICALS USA, INC.;ETINGER, MARINA, YU;BORIS, FEDOTEV