发明名称 |
Sensor and method for measuring the areal density of magnetic nanoparticles on a micro-array |
摘要 |
The present invention relates to a method and a device for magnetic detection of binding of biological molecules on a biochip. A magnetoresistive sensor device for measuring an areal density of magnetic nanoparticles on a micro-array, the magnetic nanoparticles ( 15 ) being directly or indirectly coupled to the target sample ( 11 ), is described. The magnetoresistive sensor device comprises a substrate ( 3 ) having attached thereto binding sites ( 9 ) able to selectively bind target sample ( 11 ), and a magnetoresistive sensor for detecting the magnetic field of the nanoparticles ( 15 ) coupled to the target sample. The magnetoresistive sensor comprises a plurality of magnetoresistive sensing elements ( 17, 19 ), the width and length dimensions of which are at least a factor 10 or more, preferably a factor 100 or more larger than the diameter of the nanoparticles ( 15 ). A corresponding method is described as well.
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申请公布号 |
US2005087000(A1) |
申请公布日期 |
2005.04.28 |
申请号 |
US20040498958 |
申请日期 |
2004.06.16 |
申请人 |
COEHOORN REINDER;PRINS MENNO W.J. |
发明人 |
COEHOORN REINDER;PRINS MENNO W.J. |
分类号 |
A61B5/026;A61B5/20;B01J19/00;C12M1/00;C12Q1/68;G01N15/06;G01N27/72;G01N33/543;G01N37/00;G01R33/09;G01R33/12;H01L43/08;(IPC1-7):G01N11/00;G01N33/487 |
主分类号 |
A61B5/026 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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