发明名称 |
MICROFLUIDIC AFFINITY SYSTEM USING POLYDIMETHYLSILOXANE AND A SURFACE MODIFICATION PROCESS |
摘要 |
A microfluidic affinity system is designed to recognize, capture and separate target analytes from input solutions. This microfluidic affinity system employs fluidic channels fabricated by silicon-based lithography in a silicon substrate. The fluidic channels are patterned and replicated in a substrate, preferably polydimethylsiloxane, PDMS, by pattern transfer from a silicon wafer mold with reversed patterns fabricated by lithography. A novel three-step covalent binding method for surface modification employs the following steps to covalently immobilize an affinity ligand on the substrate: 1) a plasma treatment; 2) a silanization treatment; and 3) a crosslinking treatment. |
申请公布号 |
WO2004020065(A3) |
申请公布日期 |
2005.04.28 |
申请号 |
WO2003US26749 |
申请日期 |
2003.08.28 |
申请人 |
MT TECHNOLOGIES, INC. |
发明人 |
MONTEMAGNO, CARLO, D.;CHANG, ELSA, I. |
分类号 |
B01D;B01L3/00;B05D3/00;C12M1/34;C12Q1/68;G01N33/53;G01N33/552;G01N33/68 |
主分类号 |
B01D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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