发明名称 |
TARTRATE SALTS OF 5,8,14-TRIAZATETRACYCLO[10.3.1.0<2.11>.0<4.9>]-HEXADECA-2(11),3,5,7,9-PENTAENE AND PHARMACEUTICAL COMPOSITIONS THEREOF |
摘要 |
The present invention is directed to the tartrate salts of 5,8,14-triazatetracyclo[10.3.1.0<2.11>.0<4.9>]-hexadeca-2(11),3,5,7,9-pentaene of formula (1), and pharmaceutical compositions thereof. The present invention in particular is directed to the L-tartrate salt, and further to the various polymorphs of the L-tartrate salt, including two distinct anhydrous polymorphs (referred to herein as Forms A and B) and a hydrate polymorph (referred to herein as Form C). In addition, the present invention is also directed to the D-tartrate salt of 5,8,14-triazatetracyclo[10.3.1.0<2.11>.0<4.9>]-hexadeca-2(11),3,5,7,9-pentaene and the various polymorphs thereof; as well as the D,L-tartrate salt thereof and its polymorphs, and the meso-tartrate salt thereof and its polymorphs.
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申请公布号 |
EA005528(B1) |
申请公布日期 |
2005.04.28 |
申请号 |
EA20030001121 |
申请日期 |
2002.04.26 |
申请人 |
PFIZER PRODUCTS INC. |
发明人 |
BOGLE, DAVID, EVERETT;ROSE, PETER, ROBERT;WILLIAMS, GLENN, ROBERT |
分类号 |
C07D487/08;A61K;A61K31/495;A61K31/4995;A61P;A61P1/00;A61P1/04;A61P1/14;A61P1/16;A61P3/02;A61P3/04;A61P5/14;A61P9/00;A61P9/12;A61P13/12;A61P17/00;A61P21/00;A61P25/00;A61P25/04;A61P25/06;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/32;A61P27/00;A61P29/00;A61P31/18;A61P35/00;A61P43/00;C07D;C07D221/00;C07D223/00;C07D471/00;C07D471/08;(IPC1-7):A61K31/495 |
主分类号 |
C07D487/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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