发明名称 |
SHIGA TOXIN B-SUBUNIT AS A VECTOR FOR TUMOR DIAGNOSIS AND DRUG DELIVERY TO GB3-EXPRESSING TUMORS |
摘要 |
The invention relates to new compounds for cancer therapy or diagnosis and more specifically to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb3 receptor cells, such compounds having the following formula: STxB-Z(n)-Cys-Y(m)- T wherein STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine, T is a molecule linked by a covalent bound to the S part of Cys, Y is a linker between T and Cys. |
申请公布号 |
EP1525478(A2) |
申请公布日期 |
2005.04.27 |
申请号 |
EP20030775133 |
申请日期 |
2003.07.31 |
申请人 |
INSTITUT CURIE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI) |
发明人 |
JOHANNES, LUDGER;FLORENT, JEAN-CLAUDE;GRIERSON, DAVID;MAILLARD, PHILIPPE;ROBINE, SYLVIE;ROGER, JACKY |
分类号 |
A61K38/00;A61K41/00;A61K47/48;A61K49/00;A61K49/14;C07K14/25;C07K14/36;G01N33/574;(IPC1-7):G01N33/574 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|