发明名称 |
Screening and therapeutic methods for promoting wakefulness and sleep |
摘要 |
The invention provides methods of screening for a compound for promoting wakefulness in a mammal. The method is practiced by providing a compound that is a PrRP receptor agonist and determining the ability of the compound to promote wakefulness. Also provided by the invention are methods of screening for a compound for promoting sleep in a mammal. The methods are practiced by providing a compound that is a PrRP receptor antagonist and determining the ability of the compound to promote sleep. In addition, the invention provides a method of promoting wakefulness in a mammal. The method is practiced by administering to a mammal an effective amount of a PrRP receptor agonist. The invention further provides a method of promoting sleep in a mammal. The method is practiced by administering to a mammal an effective amount of a PrRP receptor antagonist.
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申请公布号 |
US6884596(B2) |
申请公布日期 |
2005.04.26 |
申请号 |
US20010932161 |
申请日期 |
2001.08.17 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CIVELLI OLIVIER;LIN STEVEN |
分类号 |
A61K31/00;A61P5/02;A61P5/04;A61P25/08;G01N33/74;(IPC1-7):G01N33/53;G01N33/566;G01N33/567;A61K38/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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