Hydrolysis of epoxides containing trifluoromethyl groups, useful e.g. as pharmaceuticals or their intermediates, using a fungal epoxide hydrolase with high enantioselectivity

摘要

Method for hydrolyzing an epoxide (I) containing one or more trifluoromethyl groups by treating it, in presence of water, with a protein (II) having epoxide hydrolase (EH) activity, so as to open the ring with formation of a vic-diol (III).