| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a new technique for synthesizing a cyclic nonprotein-constituting amino acid having a 4-aminopiperidine-4-carboxylic acid structure. <P>SOLUTION: The amino acid represented by formula (5)-1 (wherein P<SP>1</SP>is a protective group for the carboxylic acid; and P<SP>2</SP>is a protective group for the amino group) or its deprotection product is synthesized by passing through a step (I) of subjecting a malonic acid derivative or a glycine derivative to aldehyde formation, a step (II) of subjecting the dialdehyde compound formed in the step (I) and an amine to condensation cyclization, a step (III) of reducing the dihydropyridine compound formed in the step (II), a step (IV) of causing the Curtius rearrangement of the piperidine compound formed in the step (III) and the like. By this method, amino acid compounds having various kinds of substituents introduced as R can be obtained. <P>COPYRIGHT: (C)2005,JPO&NCIPI</p> |
