PELLETS CONTAINING A PHARMACEUTICAL INGREDIENT

摘要

The invention relates to pellets containing a pharmaceutical ingredient, namely 5-chloro-4-[{3-({2-(3,4-dimethoxyphenyl)ethyl}methylamino)-propyl}amino]-3 (2H)-pyridazinone (E)-2-butene-dioate (1 : 1) (CAS: 190333-92-7), and a process for the preparation thereof. The pellets according to the invention are nearly spherical in shape and contain, in addition to the active ingredient, 10 to 60 % by weight of sodium chloride and/or potassium chloride, 10 to 60 % by weight of micro-crystalline cellulose and optionally other pharmaceutically acceptable excipients and/or pelletization promoting additives. Said pellets are particularly suitable to be coated with a layer ensuring a controlled release of the active ingredient.